关于辛吲哚美辛和吲哚美辛与人血清白蛋白的结合
On the binding of cinmetacin and indomethacin to human serum albumin.
作者信息
Montero M T, Pouplana R, Valls O, García S
出版信息
J Pharm Pharmacol. 1986 Dec;38(12):925-7. doi: 10.1111/j.2042-7158.1986.tb03386.x.
Abstract
The binding of two non-steroidal anti-inflammatory drugs, indomethacin and cinmetacin, to human serum albumin was studied by dynamic dialysis at 37 degrees C and pH 7.4. Cinmetacin is bound more than indomethacin. The affinity constant for the primary binding site is 4.28 X 10(6) M-1 for cinmetacin and 1.4 X 10(6) M-1 for indomethacin. The protein binding of indomethacin is decreased in the presence of cinmetacin.
摘要
在37摄氏度和pH值为7.4的条件下，通过动态透析法研究了两种非甾体抗炎药吲哚美辛和辛吲哚美辛与人血清白蛋白的结合情况。辛吲哚美辛的结合程度高于吲哚美辛。辛吲哚美辛主要结合位点的亲和常数为4.28×10⁶ M⁻¹，吲哚美辛为1.4×10⁶ M⁻¹。在存在辛吲哚美辛的情况下，吲哚美辛的蛋白结合率降低。
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