原发性胆汁性胆管炎的贝特类药物治疗：有何炒作？
Fibrates for Primary Biliary Cholangitis: What's All the Hype?
机构信息
University of Miami Miller School of Medicine Division of Hepatology.
出版信息
Ann Hepatol. 2017 Sep-Oct;16(5):704-706. doi: 10.5604/01.3001.0010.2709.
PMID:28809729
Abstract
Ursodeoxycholic acid is the first-line therapy for primary biliary cholangitis. However, a subset of patients fail to show biochemical response. For these patients, adjuvant therapies are warranted. Obeticholic acid was conditionally approved as a second-line drug. Evidence is building up in favor of fibrates, which are available for off-label use.
摘要
熊去氧胆酸是原发性胆汁性胆管炎的一线治疗药物。然而，有一部分患者未能显示出生化应答。对于这些患者，需要辅助治疗。奥贝胆酸被有条件批准为二线药物。越来越多的证据支持纤维酸类药物，这些药物可用于标签外使用。
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