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将丙型肝炎感染供体的肾移植到丙型肝炎未感染受者中:重新思考 Thinker 试验。

Transplanting Kidney Allografts from Hepatitis C Infected Donors into Hepatitis C Uninfected Recipients: Re-Thinking the Thinker Trial.

机构信息

University of British Columbia, Vancouver, BC, Canada Division of Gastroenterology.

出版信息

Ann Hepatol. 2017 Sep-Oct;16(5):702-703. doi: 10.5604/01.3001.0010.2708.

DOI:10.5604/01.3001.0010.2708
PMID:28809730
Abstract

In the not so distant past, organs from hepatitis C infected donors were either discarded or rarely transplanted into HCV viremic recipients - but never allocated to non-infected patients. However, the simplicity, ease and unprecedented success rates of HCV direct acting antiviral regimens has raised the possibility of utilizing such organs in an attempt to expand the donor pool. The thinker trial reports the first of such attempts. However, caution must be exercised prior to the widespread adoption of such strategy.

摘要

在不久的过去,来自丙型肝炎病毒(HCV)感染者的器官不是被丢弃就是很少被移植到 HCV 病毒血症受者中——但从未分配给非感染者。然而,HCV 直接作用抗病毒药物治疗方案的简单、方便和前所未有的成功率,提高了在试图扩大供体库的情况下使用这些器官的可能性。该思维试验报告了首例此类尝试。然而,在广泛采用这种策略之前,必须谨慎行事。

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