基于靶标与模拟靶标同步循环扩增策略原位生成电化学发光DNA纳米花作为粘蛋白1检测的信号标签
In situ generation of electrochemiluminescent DNA nanoflowers as a signal tag for mucin 1 detection based on a strategy of target and mimic target synchronous cycling amplification.
作者信息
Li Sheng-Kai, Chen An-Yi, Niu Xiao-Xue, Liu Zhi-Ting, Du Min, Chai Ya-Qin, Yuan Ruo, Zhuo Ying
机构信息
Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
出版信息
Chem Commun (Camb). 2017 Aug 24;53(69):9624-9627. doi: 10.1039/c7cc04747a.
A sensitive electrochemiluminescent (ECL) aptasensor consisting of a novel ECL signal tag of DNA nanoflowers (DNA NFs) and a highly efficient target conversion strategy for the MUC1 assay was developed, which not only increased the stability for luminophore loading, but also greatly improved the detection sensitivity.
开发了一种灵敏的电化学发光（ECL）适体传感器，其由新型DNA纳米花（DNA NFs）电化学发光信号标签和用于MUC1检测的高效靶标转换策略组成，该策略不仅提高了发光体负载的稳定性，还大大提高了检测灵敏度。
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