甲状腺乳头状癌筛状型的细胞质脂质蓄积特征。
Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma.
机构信息
Department of Clinical Laboratory, Kuma Hospital, Kobe, Japan.
出版信息
Pathobiology. 2017;84(5):251-257. doi: 10.1159/000477910. Epub 2017 Aug 16.
OBJECTIVE
The purpose of this study was to clarify the diagnostic significance of cytoplasmic lipid accumulation (CLIA) in the cribriform variant of papillary thyroid carcinoma (CV-PTC).
METHODS
We performed a histological, immunohistochemical, and cytological examination of 35 CV-PTC cases at the Kuma Hospital. CLIA was defined as bubble-like multivacuolation in cytoplasm with distinct cell border. We also examined 100 conventional PTC (con-PTC) cases as controls.
RESULTS
Histological analysis showed the presence of carcinoma cells with CLIA in 60.0% of CV-PTC and 5.0% of con-PTC cases. The vacuoles tended to distribute in the subnuclear portion of carcinoma cells showing papillary growth. They were positive for oil red O staining and adipophilin. The carcinoma cells without the vacuoles showed a subnuclear dot-like expression for adipophilin in CV-PTC cases, but not in the con-PTC cases. Cytological analysis showed CLIA in 17 (54.8%) of the 31 CV-PTC cases, but not in the con-PTC cases.
CONCLUSION
This is the first study to report the presence of carcinoma cells with CLIA in CV-PTC. The subnuclear dot-like expression of adipophilin may be characteristic of CV-PTC. These findings might be related to degenerative changes occurring in CV-PTC.
目的
本研究旨在阐明滤泡型甲状腺乳头状癌（CV-PTC）中细胞质脂质蓄积（CLIA）的诊断意义。
方法
我们对久留米医院的 35 例 CV-PTC 病例进行了组织学、免疫组织化学和细胞学检查。CLIA 定义为细胞质中具有明显细胞边界的泡状多空泡化。我们还检查了 100 例常规甲状腺乳头状癌（con-PTC）作为对照。
结果
组织学分析显示，60.0%的 CV-PTC 和 5.0%的 con-PTC 病例存在具有 CLIA 的癌细胞。空泡倾向于分布在表现出乳头状生长的癌细胞的核下部分。它们对油红 O 染色和脂联素呈阳性。在 CV-PTC 病例中，无空泡的癌细胞在核下部分呈现点状脂联素表达，但在 con-PTC 病例中则没有。细胞学分析显示，31 例 CV-PTC 病例中有 17 例（54.8%）存在 CLIA，但 con-PTC 病例则没有。
结论
这是第一项报道 CV-PTC 中存在具有 CLIA 的癌细胞的研究。脂联素的核下点状表达可能是 CV-PTC 的特征。这些发现可能与 CV-PTC 中发生的退行性变化有关。
Zotero 插件