Mohan Pazhanivel, Sundar Varun, Bhaskar Emmanuel, Anthony Syluvai
Department of Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, 4th Floor, Super Specialty Block, Dhanvantari Nagar, Puducherry, 605006 India.
Community Research Network, No: 7, Manickavasagar Street, Gandhinagar, Saligramam, Chennai, India.
Indian J Clin Biochem. 2017 Jul;32(3):337-342. doi: 10.1007/s12291-016-0616-3. Epub 2016 Sep 17.
Alanine aminotransferase (ALT) is the most common and cost effective screening test for asymptomatic liver disease. There is paucity of data on normal ALT among healthy individuals in India. An observational cross sectional study was conducted from January to July 2013 to estimate the upper limit of normal for ALT in healthy south Indian population. Adults undergoing voluntary or pre-employment health screening were included. Those with current and past alcoholism or smoking, acute illness or hospitalization during preceding 12 months, non-steroidal anti-inflammatory or over the counter medication use within a month, current or past intake of herbal medications, any chronic medical illness, abnormal body mass index (BMI), fatty liver in ultrasound, abnormality in haemoglobin, platelet count, blood sugar, creatinine, lipid profile and thyroid function test and positive serology (Hepatitis B, C or HIV) were excluded. A total of 2600 subjects were screened. 344 were included for analysis. Mean age was 35 years in men and 34.83 years in women, with a mean BMI of 22.2 kg/m in men and 21.8 kg/m in women. The mean ALT in men and women were 21.87 ± 2.9 (97.5th percentile 28 U/L) and 19.35 ± 3.3 (97.5th percentile 24 U/L) respectively. In conclusion, mean and upper limit of ALT (97.5th percentile) in south Indian men was 21.87 and 28 IU/L and women were 19.35 and 24 IU/L respectively. There is a need to re-consider ALT levels in our population for better detection of individuals at risk for liver disease.
丙氨酸氨基转移酶（ALT）是无症状肝病最常用且性价比最高的筛查检测项目。关于印度健康个体中正常ALT水平的数据较少。2013年1月至7月进行了一项观察性横断面研究，以估计健康的南印度人群中ALT的正常上限。纳入了接受自愿或入职前健康筛查的成年人。排除了当前或既往有酗酒或吸烟史、在过去12个月内有急性疾病或住院史、在一个月内使用过非甾体抗炎药或非处方药物、当前或既往服用过草药、任何慢性疾病、异常体重指数（BMI）、超声检查发现脂肪肝、血红蛋白、血小板计数、血糖、肌酐、血脂谱和甲状腺功能检查异常以及血清学阳性（乙肝、丙肝或艾滋病毒）的个体。共筛查了2600名受试者。344名被纳入分析。男性的平均年龄为35岁，女性为34.83岁，男性的平均BMI为22.kg/m²，女性为21.8kg/m²。男性和女性的平均ALT分别为21.87±2.9（第97.5百分位数为28U/L）和19.35±3.3（第97.5百分位数为24U/L）。总之，南印度男性ALT的平均值和上限（第97.5百分位数）分别为21.87和28IU/L，女性分别为19.35和24IU/L。有必要重新考虑我们人群中的ALT水平，以便更好地检测有肝病风险的个体。
