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基于参数设计的新一代脑积水脑室导管

Next generation of ventricular catheters for hydrocephalus based on parametric designs.

作者信息

Galarza M, Giménez A, Amigó J M, Schuhmann M, Gazzeri R, Thomale U, McAllister J P

机构信息

Regional Service of Neurosurgery, University of Murcia, Murcia, Spain.

Operations Research Center, University Miguel Hernández de Elche, Alacant, Spain.

出版信息

Childs Nerv Syst. 2018 Feb;34(2):267-276. doi: 10.1007/s00381-017-3565-0. Epub 2017 Aug 15.

DOI:10.1007/s00381-017-3565-0
PMID:28812141
Abstract

BACKGROUND

The flow pattern of the cerebrospinal fluid is probably the most important factor related to obstruction of ventricular catheters during the normal treatment of hydrocephalus. To better comprehend the flow pattern, we have carried out a parametric study via numerical models of ventricular catheters. In previous studies, the flow was studied under steady and, recently, in pulsatile boundary conditions by means of computational fluid dynamics (CFD) in three-dimensional catheter models.

OBJECTIVE

This study aimed to bring in prototype models of catheter CFD flow solutions as well to introduce the theory behind parametric development of ventricular catheters.

METHODS

A preceding study allowed deriving basic principles which lead to designs with improved flow patterns of ventricular catheters. The parameters chosen were the number of drainage segments, the distances between them, the number and diameter of the holes on each segment, as well as their relative angular position.

RESULTS

CFD results of previously unreleased models of ventricular catheter flow solutions are presented in this study. Parametric development guided new designs with better flow distribution while lowering the shear stress of the catheters holes. High-resolution 3D printed catheter solutions of three models and basic benchmark testing are introduced as well.

CONCLUSIONS

The next generation of catheter with homogeneous flow patterns based on parametric designs may represent a step forward for the treatment of hydrocephalus, by possibly broadening their lifespan.

摘要

背景

在脑积水的常规治疗过程中,脑脊液的流动模式可能是与脑室导管阻塞相关的最重要因素。为了更好地理解流动模式,我们通过脑室导管的数值模型进行了参数研究。在先前的研究中,通过三维导管模型中的计算流体动力学(CFD)在稳定边界条件下以及最近在脉动边界条件下研究了流动情况。

目的

本研究旨在引入导管CFD流动解决方案的原型模型,并介绍脑室导管参数化开发背后的理论。

方法

先前的一项研究得出了一些基本原则,这些原则可用于设计具有改善的脑室导管流动模式的产品。所选择的参数包括引流段的数量、它们之间的距离、每个段上孔的数量和直径,以及它们的相对角位置。

结果

本研究展示了先前未发布的脑室导管流动解决方案模型的CFD结果。参数化开发指导了新的设计,这些设计具有更好的流动分布,同时降低了导管孔处的剪切应力。还介绍了三种模型的高分辨率3D打印导管解决方案以及基本的基准测试。

结论

基于参数化设计的具有均匀流动模式的下一代导管可能代表了脑积水治疗的一个进步,因为这可能会延长它们的使用寿命。

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Parametric study of ventricular catheters for hydrocephalus.脑积水脑室导管的参数研究。
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Pulsatile flow in ventricular catheters for hydrocephalus.用于脑积水治疗的脑室导管中的脉动血流。
Philos Trans A Math Phys Eng Sci. 2017 Jun 28;375(2096). doi: 10.1098/rsta.2016.0294.
2
Influence of the hole geometry on the flow distribution in ventricular catheters for hydrocephalus.脑室导管孔洞几何形状对脑积水引流中血流分布的影响。
Biomed Eng Online. 2016 Jul 15;15 Suppl 1(Suppl 1):71. doi: 10.1186/s12938-016-0182-1.
3
Ventricular catheter development: past, present, and future.心室导管的发展:过去、现在和未来。
结构改变对心室导管中液体流动相对阻力的影响。
Front Bioeng Biotechnol. 2025 Jan 29;12:1519499. doi: 10.3389/fbioe.2024.1519499. eCollection 2024.
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The effects of ventricle geometries and boundary conditions on computational modeling of ventriculoperitoneal catheters.脑室几何形状和边界条件对脑室腹腔分流管计算建模的影响。
Comput Biol Med. 2025 Mar;187:109776. doi: 10.1016/j.compbiomed.2025.109776. Epub 2025 Feb 3.
5
Dual catheter and double-lumen cerebrospinal fluid shunt systems with backflow mechanisms.带反流机制的双导管和双腔脑脊髓液分流系统。
Childs Nerv Syst. 2024 Jan;40(1):135-143. doi: 10.1007/s00381-023-06101-0. Epub 2023 Jul 29.
6
Polyvinylpyrrolidone-coated catheters decrease choroid plexus adhesion and improve flow/pressure performance in an in vitro model of hydrocephalus.聚乙烯吡咯烷酮涂层导管可减少脉络丛粘连,并改善体外脑积水模型中的流动/压力性能。
Childs Nerv Syst. 2024 Jan;40(1):115-121. doi: 10.1007/s00381-023-06058-0. Epub 2023 Jul 7.
7
Proximal ventricular shunt catheter occlusion model.近端脑室分流导管闭塞模型。
Childs Nerv Syst. 2023 Jan;39(1):205-210. doi: 10.1007/s00381-022-05689-z. Epub 2022 Sep 28.
8
Computational Modeling and Simulation to Quantify the Effects of Obstructions on the Performance of Ventricular Catheters Used in Hydrocephalus Treatment.计算建模与仿真定量分析脑积水治疗中使用的脑室导管的性能障碍影响
Methods Mol Biol. 2022;2394:767-786. doi: 10.1007/978-1-0716-1811-0_40.
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High-resistance proximal "scaled" ventricular catheters.高阻力近端“鳞片状”心室导管。
Childs Nerv Syst. 2022 Feb;38(2):333-341. doi: 10.1007/s00381-021-05390-7. Epub 2021 Oct 15.
10
A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure.在剪切应力下对星形胶质细胞细胞因子分泌进行高分辨率实时定量,以研究脑积水分流失败。
Commun Biol. 2021 Mar 23;4(1):387. doi: 10.1038/s42003-021-01888-7.
J Neurosurg. 2016 Dec;125(6):1504-1512. doi: 10.3171/2015.12.JNS151181. Epub 2016 Mar 4.
4
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Acta Neurochir (Wien). 2016 Jan;158(1):109-15; discussion 115-6. doi: 10.1007/s00701-015-2618-y. Epub 2015 Nov 3.
5
Basic cerebrospinal fluid flow patterns in ventricular catheters prototypes.脑室导管原型中的基本脑脊液流动模式。
Childs Nerv Syst. 2015 Jun;31(6):873-84. doi: 10.1007/s00381-015-2651-4. Epub 2015 Feb 17.
6
New designs of ventricular catheters for hydrocephalus by 3-D computational fluid dynamics.通过三维计算流体动力学设计脑积水脑室导管的新方法。
Childs Nerv Syst. 2015 Jan;31(1):37-48. doi: 10.1007/s00381-014-2477-5. Epub 2014 Aug 6.
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A new look at cerebrospinal fluid circulation.脑脊液循环的新视角。
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Neurosurgery. 2012 Jun;70(6):1589-601; discussion 1601-2. doi: 10.1227/NEU.0b013e318244695f.