Al-Adnani Mudher
1 Department of Cellular Pathology, St Thomas' Hospital, London, UK.
Pediatr Dev Pathol. 2017 Sep-Oct;20(5):444-448. doi: 10.1177/1093526617689895. Epub 2017 Jan 25.
Soft tissue perineurioma is a rare benign peripheral nerve sheath tumor, especially in children. This manuscript presents an unusual case of soft tissue perineurioma in a 10-year-old boy with neurofibromatosis type 1. The patient presented with a lump in the region of the right breast. A subcutaneous, well circumscribed mass was removed. The cut surface was cream with a vaguely nodular appearance. Histology showed a spindle cell lesion with variable architecture and biphasic morphology. There was no nuclear atypia or pleomorphism. The differential diagnosis and other soft tissue lesions that can be seen in neurofibromatosis type 1 are discussed.
软组织束状神经瘤是一种罕见的良性周围神经鞘瘤，在儿童中尤为少见。本文报告了一例10岁1型神经纤维瘤病男孩患软组织束状神经瘤的不寻常病例。该患者右侧乳房区域出现一个肿块。切除了一个皮下、边界清晰的肿物。切面呈淡黄色，外观隐约呈结节状。组织学检查显示为梭形细胞病变，结构多样，具有双相形态。未见核异型性或多形性。文中讨论了鉴别诊断以及1型神经纤维瘤病中可见的其他软组织病变。
