Ge Hong-Xing, Zou Fu-Man, Li Yan, Liu An-Min, Tu Min
a Department of Orthopaedics , Second People's Hospital of Jingmen , Jingmen , China.
b Department of General Medicine , Second People's Hospital of Jingmen , Jingmen , China.
J Recept Signal Transduct Res. 2017 Oct;37(5):431-436. doi: 10.1080/10799893.2017.1360353.
Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway.
In this study, we have reviewed the recent updates on the association of JNK pathway with OA.
In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc., and collected the most relevant papers of JNK signaling pathway involved in the pathogenesis and therapeutics of OA Results: JNK has been shown by scientific studies to be activated (phosphorylated) in OA that can play a key role in the cartilage destruction. Activation of JNK causes the phosphorylation of c-Jun that causes decreased proteoglycan synthesis and enhanced production of matrix metalloproteinase 13 (MMP-13). Overproduction of MMP-13 by chondrocytes plays a central role in cartilage degeneration in OA. Thus, targeting JNK pathway might be a promising therapeutic application for the prevention and treatment of OA. A number of JNK-inhibitors have been used in vitro and in vivo studies; however, not yet been translated into human use.
This review study indicates that JNK pathway plays an important role in development and progression of OA, and targeting the JNK pathway might be a potential approach for the treatment of OA in future.
骨关节炎（OA）是一种常见的慢性退行性关节疾病，会导致身体残疾并降低生活质量。不同的生化信号通路参与了OA的进展，包括c-Jun氨基末端激酶（JNK）信号转导通路。
在本研究中，我们回顾了JNK通路与OA关联的最新进展。
在本综述中，我们检索了PubMed、谷歌学术、Medline、Scopus等数据库，并收集了与JNK信号通路参与OA发病机制和治疗相关的最具相关性的论文。结果：科学研究表明，JNK在OA中被激活（磷酸化），这在软骨破坏中可能起关键作用。JNK的激活导致c-Jun磷酸化，进而导致蛋白聚糖合成减少和基质金属蛋白酶13（MMP-13）产生增加。软骨细胞过度产生MMP-13在OA的软骨退变中起核心作用。因此，靶向JNK通路可能是预防和治疗OA的一种有前景的治疗方法。许多JNK抑制剂已用于体外和体内研究；然而，尚未转化为人体应用。
本综述研究表明，JNK通路在OA的发生和发展中起重要作用，靶向JNK通路可能是未来治疗OA的一种潜在方法。
