Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Sci Rep. 2017 Aug 16;7(1):8431. doi: 10.1038/s41598-017-08762-9.
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC - MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This "multi-color" MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.
可注射磁共振成像（MRI）对比剂已被广泛用于为临床和基础科学成像研究提供疾病的关键评估。随着分子成像对比剂针对生物标志物的特异性靶向的出现，可用的 MRI 对比剂的范围近年来已经扩大。不幸的是，由于 MRI 一次只能动态测量单一试剂的能力，因此协同应用超过一种单一的分子对比剂受到了限制。在这项研究中，描述了一种新的双对比 - 磁共振指纹图谱（DC - MRF）方法，该方法可以在同时给药后检测和独立定量多个 MRI 对比剂的局部浓度。这种“多色”MRI 方法提供了同时监测多种分子的机会，并为分子成像对比剂的最终临床转化提供了实用的定量成像框架。
