Anand Vibha, Cahan Amos, Ghosh Soumya
IBM T.J. Watson Research Center, Cambridge, MA.
AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:37-47. eCollection 2017.
ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it's important to understand the "topic" areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as 'Cardiovascular disorders', Heart & Brain conditions', or 'Breast & Prostate cancer' as well as trials registered for general health. General health trials are less likely to be FDA regulated, but both health and pain management, as well as surgical, heart, and brain trials have upward trend in recent years while advanced cancer trials have downward trended. Our model derives unique insights from metadata associated with each topic area.
ClinicalTrials.gov于2000年设立，作为基于网络的人类受试者临床试验注册库。强制注册始于2008年。鉴于已有十多年的注册试验，从这一资源了解“主题”领域及其随时间的演变很重要。这些信息可能有助于识别当前的知识空白。我们使用动态主题模型（DTM）方法来发现过去17年中的主题及其演变。我们的模型表明，存在特定疾病或器官的试验，如“心血管疾病”、“心脏与脑部疾病”或“乳腺癌与前列腺癌”，以及为一般健康状况注册的试验。一般健康试验受美国食品药品监督管理局（FDA）监管的可能性较小，但健康与疼痛管理试验以及外科、心脏和脑部试验近年来呈上升趋势，而晚期癌症试验呈下降趋势。我们的模型从与每个主题领域相关的元数据中得出了独特的见解。
