Cardellini P, Sala M
Comp Biochem Physiol A Comp Physiol. 1987;86(1):85-9. doi: 10.1016/0300-9629(87)90281-7.
In the anuran Pelodytes punctatus the larval hemoglobin produces five electrophoretic bands. In the premetamorphic period, two other bands appear which are typical of the adult. They gradually substitute the larval bands completely as in other anurans. The pathway of the hemoglobin shift indicates that the synthesis of the adult fractions does not depend on the thyroid hormones for its activation, whereas the disappearance of the larval fractions depends on the destruction of the "larval" red blood cell line. As in other species of anurans which are considered primitive, the hemoglobinic change of Pelodytes punctatus starts earlier and develops slower than in other more evolved anurans. In normal developing specimens of Pelodytes punctatus the change in the hemoglobin fractions occurs very slowly and finishes 4 weeks after the metamorphosis, whereas in "hibernated" specimens the rate of change is higher and it ends earlier, probably as a consequence in the retarded larvae, of the increased sensibility of the hemopoietic tissues to the metamorphosis factors.
在无尾两栖动物斑点螈中，幼体血红蛋白产生五条电泳带。在变态前期，出现另外两条典型的成体血红蛋白电泳带。如同在其他无尾两栖动物中一样，它们逐渐完全取代幼体血红蛋白带。血红蛋白转换途径表明，成体血红蛋白组分的合成并不依赖甲状腺激素来激活，而幼体血红蛋白组分的消失则依赖于“幼体”红细胞系的破坏。与其他被认为是原始物种的无尾两栖动物一样，斑点螈的血红蛋白变化比其他进化程度更高的无尾两栖动物开始得更早，发展得更慢。在正常发育的斑点螈标本中，血红蛋白组分的变化非常缓慢，在变态后4周完成，而在“冬眠”标本中，变化速率更高且结束得更早，这可能是由于幼体发育迟缓，造血组织对变态因子的敏感性增加所致。
