Weiss M, Carson R S
Comp Biochem Physiol A Comp Physiol. 1987;86(2):361-5. doi: 10.1016/0300-9629(87)90343-4.
The induction of adrenocortical special zone (S.Z.) by gonadotrophin administration was studied in male brush tailed possums. Castrated males injected with porcine FSH (NIH-FSH-P2) formed well developed S.Z.s, varying in sizes from 5-20% of the gland's volume. Pregnant mare serum gonadotrophin (PMSG) was ineffective. From adrenal homogenates of FSH treated possums incubated with [3H]-progesterone the major conversion products were 5 beta-reduced steroid metabolites (72%) and cortisol (4%). The conversion products from adrenals of saline and PMSG treated males were cortisol and corticosterone (65%). Of the ten untreated castrates, one had a well developed S.Z. and two had S.Z.s at an early stage of development. Significant 5 beta-reduction of [3H]progesterone was only found in one animal. The plasma FSH concentrations were in intact males 317 +/- 41 ng rat FSH ml-1 (mean +/- SEM) and in castrates 769 +/- 64. The possible reasons for the lack of spontaneous S.Z. formation in intact males are discussed.
在雄性帚尾袋貂中研究了促性腺激素给药对肾上腺皮质特殊区（S.Z.）的诱导作用。注射猪促卵泡激素（NIH - FSH - P2）的去势雄性形成了发育良好的S.Z.，其大小占腺体体积的5% - 20%不等。孕马血清促性腺激素（PMSG）无效。用[³H] - 孕酮孵育经促卵泡激素处理的袋貂的肾上腺匀浆，主要转化产物是5β - 还原类固醇代谢物（72%）和皮质醇（4%）。用生理盐水和PMSG处理的雄性肾上腺的转化产物是皮质醇和皮质酮（65%）。在十只未处理的去势动物中，一只具有发育良好的S.Z.，两只处于发育早期阶段。仅在一只动物中发现[³H]孕酮有显著的5β - 还原。完整雄性的血浆促卵泡激素浓度为317 ± 41 ng大鼠促卵泡激素/毫升（平均值 ± 标准误），去势动物为769 ± 64。讨论了完整雄性缺乏自发形成S.Z.的可能原因。
