Tönges Lars, Ceballos-Baumann Andrés, Honig Holger, Storch Alexander, Jost Wolfgang H
Ruhr-Universität Bochum, St. Josef-Hospital, Klinik für Neurologie.
Schön Klinik München-Schwabing, Neurologie und klinische Neurophysiologie.
Fortschr Neurol Psychiatr. 2017 Sep;85(9):516-535. doi: 10.1055/s-0043-110095. Epub 2017 Aug 17.
Parkinson's disease is the second most common neurodegenerative illness after Alzheimer's disease. In its advanced stages, it is characterized by various special symptoms. In addition to non-motor signs, motor complications are most prominent and most often can only be inadequately improved with pulsatile oral therapies. However, with the aid of continuous dopaminergic stimulation, improvements can be achieved even in advanced stages of the disease. This will not only alleviate motor and non-motor symptoms, but will also lead to a better quality of life. In this context, continuous subcutaneous apomorphine administration by means of a pump has been well established. Its benefits, indications, limitations and practical implementation will be thoroughly described in the expert recommendation. Particularly noteworthy is the rather broad therapeutic window of apomorphine pump treatment, which can be optimally utilized by simple drug titration in a rapidly reversible process. This article presents the results of an expert meeting on apomorphine therapy which took place on July 6, 2016, in Frankfurt (M), Germany.
帕金森病是仅次于阿尔茨海默病的第二常见神经退行性疾病。在其晚期,它具有各种特殊症状。除了非运动症状外,运动并发症最为突出,而且采用脉冲式口服疗法往往只能得到不充分的改善。然而,借助持续多巴胺能刺激,即使在疾病晚期也能实现改善。这不仅会减轻运动和非运动症状,还会带来更好的生活质量。在这种情况下,通过泵持续皮下注射阿扑吗啡已得到充分确立。其益处、适应症、局限性和实际应用将在专家推荐中进行全面描述。特别值得注意的是阿扑吗啡泵治疗相当宽的治疗窗,通过简单的药物滴定在快速可逆的过程中可以得到最佳利用。本文介绍了2016年7月6日在德国美因河畔法兰克福举行的一次关于阿扑吗啡治疗的专家会议的结果。