Bethge N, Ahuja S, Diel F
Exp Clin Endocrinol. 1986 Dec;88(3):365-72. doi: 10.1055/s-0029-1210619.
The presence of calcitonin, somatostatin-like immunoreactivity and carcinoembryonic antigen in tumor tissues (surgically obtained) and identified by the peroxidase-antiperoxidase technique, is reported in two sisters suffering from familial thyroid medullary carcinoma. C-cell hyperplasia occurred in both individuals. Preoperatively, both patients had elevated calcitonin serum levels (290 pM, 991.8 ng/l), and carcinoembryonic antigen (60 micrograms/l). No ACTH or thyroglobulin immunoreactivity could be found in the tumor tissue. After thyroidectomy, 131I-treatment and percutaneous radiation, somatostatin-like immunoreactivity and carcinoembryonic antigen plasma levels were in the normal range, whereas calcitonin was still elevated. It is proposed that calcitonin, somatostatin, and carcinoembryonic antigen are produced by the thyroid medullary carcinoma.
据报道，在两名患有家族性甲状腺髓样癌的姐妹中，通过过氧化物酶-抗过氧化物酶技术在手术获取的肿瘤组织中发现了降钙素、生长抑素样免疫反应性和癌胚抗原。两名患者均出现C细胞增生。术前，两名患者的血清降钙素水平均升高（290 pM，991.8 ng/l），癌胚抗原水平也升高（60微克/升）。在肿瘤组织中未发现促肾上腺皮质激素或甲状腺球蛋白免疫反应性。甲状腺切除、131I治疗和经皮放射治疗后，生长抑素样免疫反应性和血浆癌胚抗原水平恢复正常，而降钙素水平仍升高。研究表明，甲状腺髓样癌可产生降钙素、生长抑素和癌胚抗原。
