Obaseki A O, Coker H B
J Pharm Pharmacol. 1987 Feb;39(2):142-4. doi: 10.1111/j.2042-7158.1987.tb06964.x.
The anticoagulant activities of 6-, 7-, 8-, 4'-hydroxy, 6-chloro- and 6-bromowarfarin were determined in rabbits after intraperitoneal administration of 16.2 mumol kg-1 over 96 h. Substitution on the 4-hydroxycoumarin moiety resulted in reduction of the anticoagulant activity. 6-Chlorowarfarin was more potent than 6-bromowarfarin suggesting that the molecular size of 4-hydroxycoumarin moiety may be crucial for biological activity.
给兔子腹腔注射16.2微摩尔/千克剂量的6-、7-、8-、4'-羟基、6-氯和6-溴华法林，持续96小时后，测定其抗凝活性。4-羟基香豆素部分的取代导致抗凝活性降低。6-氯华法林比6-溴华法林的效力更强，这表明4-羟基香豆素部分的分子大小可能对生物活性至关重要。
