Londong W
Klin Wochenschr. 1986;64 Suppl 7:32-4.
Gastric injury and dyspepsia are major side-effects of acetylsalicylic acid (ASA) or most non-steroidal anti-inflammatory drugs (NSADs) which cause either gastric ulcerations or gastroduodenal erosions. There is only a limited number of trials in which the possibility of preventing or treating gastric lesions due to those drugs have been studied in man. This paper reviews trials in which H2-receptor antagonists, pirenzepine and prostaglandins have been investigated. - Pirenzepine given in antisecretory doses seems to improve gastrointestinal symptoms induced by ASA or NSADs. Cimetidine and misoprostol might prevent fecal blood loss. Gastroduodenal lesions might be prevented by pirenzepine, misoprostol and enprostil. It might be possible that cimetidine or ranitidine heal NSAD-induced peptic ulcers better than placebo in arthritic patients who stop the ingestion of NSADs. - All over the results of the cited trials are inconclusive, since the number of patients studied were too small and the design of almost all trials was incomparable. Furthermore, all cited studies do not correspond to Robert's concept of "cytoprotection", since H2-blockers, pirenzepine and prostaglandins have been applied in antisecretory doses in man.
胃损伤和消化不良是乙酰水杨酸（ASA）或大多数非甾体抗炎药（NSADs）的主要副作用，这些药物会导致胃溃疡或胃十二指肠糜烂。在人体中研究预防或治疗这些药物引起的胃部病变可能性的试验数量有限。本文综述了对H2受体拮抗剂、哌仑西平和前列腺素进行研究的试验。——以抗分泌剂量给予哌仑西平似乎可改善ASA或NSADs引起的胃肠道症状。西咪替丁和米索前列醇可能预防粪便失血。哌仑西平、米索前列醇和恩前列素可能预防胃十二指肠病变。在停止摄入NSADs的关节炎患者中，西咪替丁或雷尼替丁可能比安慰剂更有效地治愈NSADs引起的消化性溃疡。——所有引用试验的结果都不明确，因为研究的患者数量太少，而且几乎所有试验的设计都无法比较。此外，所有引用的研究都不符合罗伯特的“细胞保护”概念，因为H2阻滞剂、哌仑西平和前列腺素在人体中是以抗分泌剂量应用的。
