Scheiman J M
Am J Manag Care. 2001 Feb;7(1 Suppl):S10-4.
Gastric and duodenal injury related to nonsteroidal anti-inflammatory drug (NSAID) use is extremely common, and a variety of strategies can be employed to reduce this frequent side effect of an otherwise useful category of medications. Although the best approach may be to discontinue NSAID treatment, this is not always possible for patients with arthritis pain or for those who require low-dose aspirin therapy for underlying cardiovascular disease. In arthritis cases, one of the new cyclooxygenase-2 specific inhibitors can be used to replace a traditional NSAID, but the addition of another drug to treat and heal ulcers is normally still needed. Patients taking aspirin are also candidates for additional treatment.
与使用非甾体抗炎药（NSAID）相关的胃和十二指肠损伤极为常见，可采用多种策略来减少这类原本有用的药物频繁出现的这种副作用。尽管最佳方法可能是停用NSAID治疗，但对于有关节炎疼痛的患者或因潜在心血管疾病需要低剂量阿司匹林治疗的患者而言，这并非总是可行的。在关节炎病例中，可使用一种新型环氧化酶-2特异性抑制剂来替代传统的NSAID，但通常仍需要加用另一种药物来治疗和愈合溃疡。服用阿司匹林的患者也是额外治疗的适用对象。
