Hammer Marilyn J
Mount Sinai Hospital.
Oncol Nurs Forum. 2017 Sep 1;44(5):537-539. doi: 10.1188/17.ONF.537-539.
Pragmatic trials evaluate interventions in real-life scenarios, which differ from explanatory trials that control for numerous factors and variables to best determine causal associations. Each approach has advantages and disadvantages. Conducting pragmatic research trials while maintaining the tenets of the ethical conduct of research can sometimes be challenging, particularly regarding informed consent. In this column, distinctions between pragmatic and explanatory trials are discussed from an ethical view.
实用性试验在现实生活场景中评估干预措施，这与解释性试验不同，后者控制众多因素和变量以最佳地确定因果关联。每种方法都有优缺点。在开展实用性研究试验的同时坚持研究伦理行为的原则有时具有挑战性，尤其是在知情同意方面。在本专栏中，将从伦理角度讨论实用性试验和解释性试验之间的区别。
