Palitzsch K D, Schuler H, Schwedes U, Usadel K H
Klin Wochenschr. 1986;64 Suppl 7:93-6.
The purpose of our investigation was to study the effect of two somatostatin analogs (SMS 201-995 and 008) on duodenal ulcer disease induced by cysteamine in rats. Male Wistar rats were given cysteamine (28 mg/100 g body wt.) by rubber stomach tube three times in a single day. All animals of the test group were injected subcutaneously either with SMS 201-995 in different doses or with 008. On the 3rd day stomach, duodenum, and adrenal glands were macroscopically examined for lesions (duodenal ulceration, gastrointestinal bleeding, adrenal hemorrhage). Our results showed a dose-dependent effect of SMS 201-995 on the mortality, incidence, and intensity of cysteamine-induced duodenal lesions in rats. The incidence and the intensity of gastrointestinal bleeding and adrenal hemorrhage were also dose-dependently reduced by SMS 201-995. There was no definite effect of 008 on the mortality, incidence, or intensity of cysteamine-induced duodenal ulceration.
我们研究的目的是探讨两种生长抑素类似物（SMS 201-995和008）对大鼠半胱胺诱发的十二指肠溃疡病的影响。雄性Wistar大鼠通过橡胶胃管在一天内分三次给予半胱胺（28毫克/100克体重）。试验组的所有动物皮下注射不同剂量的SMS 201-995或008。在第3天，对胃、十二指肠和肾上腺进行宏观检查，观察病变情况（十二指肠溃疡、胃肠道出血、肾上腺出血）。我们的结果显示，SMS 201-995对大鼠半胱胺诱发的十二指肠病变的死亡率、发病率和严重程度具有剂量依赖性影响。SMS 201-995还能剂量依赖性地降低胃肠道出血和肾上腺出血的发病率和严重程度。008对半胱胺诱发的十二指肠溃疡的死亡率、发病率或严重程度没有明确影响。
