Psaros Einberg Afrodite, Duberg Ann-Sofi, Filipovich Olga, Nyström Jessica, Zhirkov Anton, Brenndörfer Erwin D, Frelin Lars, Rukoiatkina Elena, Lobzin Yuriy, Sällberg Matti, Fischler Björn, Lutckii Anton
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet.
Department of Pediatrics, Karolinska University Hospital, Stockholm.
J Pediatr Gastroenterol Nutr. 2017 Dec;65(6):608-612. doi: 10.1097/MPG.0000000000001711.
Single genetic nucleotide polymorphism (rs12979860) near the gene for interleukin 28B (IL28B) is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon-based therapies in patients with hepatitis C virus (HCV) infection. The aim of the present study was to investigate whether IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT).
Plasma samples from 59 infected women, 76 uninfected children born to infected mothers, and 47 children with known vertically transmitted HCV infection, were analysed for IL28B polymorphism and classified by the IL28B genotype (C/C, C/T, and T/T) and by viral genotype.
The proportion of children with genotype C/C was the same in the vertically infected (36%, 17/47) and the exposed uninfected children (38%, 29/76). No difference was seen when stratifying for viral genotype. There was no association between mothers' IL28B genotype and the risk of vertical transmission.
Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.
已知白细胞介素28B（IL28B）基因附近的单基因核苷酸多态性（rs12979860）对于丙型肝炎病毒（HCV）感染患者基于干扰素治疗的自发清除频率和治疗结果具有重要意义。本研究的目的是调查儿童和/或其母亲的IL28B多态性是否在HCV垂直传播（HCV-VT）中起作用。
对59名受感染女性、76名受感染母亲所生的未受感染儿童以及47名已知垂直传播HCV感染的儿童的血浆样本进行IL28B多态性分析，并根据IL28B基因型（C/C、C/T和T/T）和病毒基因型进行分类。
垂直感染儿童（36%，17/47）和暴露但未感染儿童（38%，29/76）中C/C基因型儿童的比例相同。按病毒基因型分层时未发现差异。母亲的IL28B基因型与垂直传播风险之间无关联。
无论病毒基因型如何，我们发现IL28B基因型与HCV-VT风险之间无关联。在其他情况下已显示有利的IL28B基因型CC对HCV-VT无保护作用。因此，需要探索可能与HCV-VT风险相关的其他因素。
