Fang Jiajia, Chen Sihan, Luo Cheng, Gong Qiyong, An Dongmei, Zhou Dong
Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University, Yiwu, Zhejiang, China.
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Epilepsy Res. 2017 Oct;136:109-114. doi: 10.1016/j.eplepsyres.2017.07.020. Epub 2017 Aug 1.
Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest -based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups. Increased positive functional connectivity within the Broca's region was detected mainly at the left superior frontal gyrus (Brodmann area 8), bilateral insula, and anterior and posterior cingulate in the BECTS group. No regions showed significantly decreased connection in the BECTS patients compared to the controls. This study suggested alterations in the language network that was related with the Broca's area in children with BECTS from the non-dominant side. Further studies with longitudinal assessments from the perceptive of functional neuroimaging are needed to illustrate the dynamic course of language development and corresponding neuroimaging evidence.
儿童良性中央颞区棘波癫痫（BECTS）是最常见的儿童癫痫综合征之一，与BECTS相关的语言缺陷已成为一个热门话题。本研究调查了非优势侧有棘波的BECTS儿童与健康对照相比语言网络的改变。招募了23名BECTS儿童和20名年龄匹配的健康对照。基于感兴趣区域的全脑功能连接分析用于识别两组之间布洛卡区功能连接的潜在差异。BECTS组主要在左侧额上回（布罗德曼区8）、双侧岛叶以及前扣带回和后扣带回检测到布洛卡区内正性功能连接增加。与对照组相比，BECTS患者中没有区域显示出明显减少的连接。本研究提示非优势侧BECTS儿童与布洛卡区相关的语言网络存在改变。需要从功能神经影像学角度进行纵向评估的进一步研究，以阐明语言发展的动态过程及相应的神经影像学证据。
