前列腺癌中的 microRNAs：作为生物标志物的功能作用。

MicroRNAs in prostate cancer: Functional role as biomarkers.

机构信息

Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.

Center of Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA; Department of Biological Sciences, Cleveland State University, Cleveland, OH, 44115, USA.

出版信息

Cancer Lett. 2017 Oct 28;407:9-20. doi: 10.1016/j.canlet.2017.08.011. Epub 2017 Aug 18.

DOI:10.1016/j.canlet.2017.08.011

PMID:28823964

Abstract

MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

摘要

MicroRNAs (miRNAs) 是小的内源性非编码分子，通过信使 RNA 的转录后调控来改变基因表达。有强有力的证据表明 miRNA 在癌症生物学中的作用具有作为诊断、预后和预测生物标志物的潜力。本综述总结了前列腺癌中 miRNA 失调及其作为癌基因、肿瘤抑制因子和转移调节剂的作用的最新知识。阐明 miRNA 生物学功能的新信息是有希望的，并且可能导致它们作为诊断/预后标志物的潜在有用性，并作为管理前列腺癌的有效治疗工具的发展。