Rankin A J, Wilson N, Ledsome J R
Pflugers Arch. 1987 Feb;408(2):124-8. doi: 10.1007/BF00581340.
Changes in levels of plasma immunoreactive atrial natriuretic peptide (IR-ANP) were measured in response to administration of isoproterenol in the anesthetized, vagotomized rabbit. A dose-dependent increase in plasma IR-ANP was seen in response to 10 min isoproterenol infusions between 0.1 and 10.0 micrograms/kg/min. The time course of these responses showed the maximum levels of IR-ANP to be attained 10 min after the cessation of infusion. In rabbits in which plasma vasopressin (AVP) levels were also measured, the maximum levels of AVP were attained during the infusion period. There was no correlation between levels of AVP and IR-ANP suggesting that AVP released into the plasma did not affect directly the release of IR-ANP. The changes in IR-ANP in response to isoproterenol were significantly reduced in rabbits which had been administered the beta-1-adrenoceptor blocking agent, atenolol. In six rabbits in which the vagi remained intact, the increases in IR-ANP were reduced and became significant only with 10 micrograms/kg/min isoproterenol infusion. The results demonstrate that isoproterenol infusion increases the level of plasma IR-ANP in the anesthetized rabbit and suggest that this is through an effect on the heart rather than on peripheral vessels.
在麻醉、切断迷走神经的兔中，测量给予异丙肾上腺素后血浆免疫反应性心房钠尿肽（IR-ANP）水平的变化。在以0.1至10.0微克/千克/分钟的速度输注异丙肾上腺素10分钟后，可见血浆IR-ANP呈剂量依赖性增加。这些反应的时间进程显示，输注停止后10分钟达到IR-ANP的最高水平。在同时测量血浆血管加压素（AVP）水平的兔中，AVP的最高水平在输注期间达到。AVP水平与IR-ANP水平之间无相关性，这表明释放到血浆中的AVP并未直接影响IR-ANP的释放。在给予β-1肾上腺素能阻滞剂阿替洛尔的兔中，异丙肾上腺素引起的IR-ANP变化显著减少。在6只迷走神经完整的兔中，IR-ANP的增加减少，仅在以10微克/千克/分钟的速度输注异丙肾上腺素时才变得显著。结果表明，输注异丙肾上腺素可增加麻醉兔血浆IR-ANP水平，提示这是通过对心脏而非外周血管的作用实现的。
