Institute of Molecular Medicine and Cell Research, Faculty of Medicine, Albert-Ludwigs-University Freiburg, and German Cancer Consortium (DKTK), Partner site Freiburg, Freiburg, Germany.
Theranostics. 2017 Jul 30;7(11):2965-2967. doi: 10.7150/thno.21603. eCollection 2017.
Cysteine cathepsins are a group of proteases involved in many physiological and pathological processes. Yet, the selective detection and inhibition of individual cathepsins is still challenging. This editorial is discussing the context of a recent work introducing a designed ankyrin repeat protein (DARPin) as novel approach for selective targeting of the protease cathepsin B.
半胱氨酸组织蛋白酶属于一大类蛋白酶，参与多种生理和病理过程。然而，对于特定组织蛋白酶的选择性检测和抑制仍然具有挑战性。这篇社论讨论了最近一项工作的背景，该工作介绍了一种设计的锚蛋白重复蛋白（DARPin），作为选择性靶向蛋白酶组织蛋白酶 B 的新方法。
