Moghissi K, Dixon Kate, Gibbins Sally
The Yorkshire Laser Centre, Goole and District Hospital, Goole, East Yorkshire, United Kingdom.
Surg J (N Y). 2015 Oct 15;1(1):e1-e15. doi: 10.1055/s-0035-1565246. eCollection 2015 Dec.
Clinical photodynamic therapy (PDT) has existed for over 30 years, and its scientific basis has been known and investigated for well over 100 years. The scientific foundation of PDT is solid and its application to cancer treatment for many common neoplastic lesions has been the subject of a huge number of clinical trials and observational studies. Yet its acceptance by many clinicians has suffered from its absence from the undergraduate and/or postgraduate education curricula of surgeons, physicians, and oncologists. Surgeons in a variety of specialties many with years of experience who are familiar with PDT bear witness in many thousands of publications to its safety and efficacy as well as to the unique role that it can play in the treatment of cancer with its targeting precision, its lack of collateral damage to healthy structures surrounding the treated lesions, and its usage within minimal access therapy. PDT is closely related to the fluorescence phenomenon used in photodiagnosis. This review aspires both to inform and to present the clinical aspect of PDT as seen by a surgeon.
临床光动力疗法（PDT）已经存在了30多年，其科学基础早在100多年前就已为人所知并得到研究。PDT的科学基础坚实，其在许多常见肿瘤性病变的癌症治疗中的应用一直是大量临床试验和观察性研究的主题。然而，许多临床医生对它的接受程度却受到影响，因为外科医生、内科医生和肿瘤学家的本科和/或研究生教育课程中都没有它。许多有多年经验、熟悉PDT的各专业外科医生在成千上万的出版物中证明了它的安全性和有效性，以及它在癌症治疗中可以发挥的独特作用，即靶向精确、对治疗病变周围的健康结构无附带损害，以及可在微创治疗中使用。PDT与用于光诊断的荧光现象密切相关。这篇综述旨在介绍外科医生所看到的PDT的临床情况并提供相关信息。
