National Tuberculosis Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing, Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, China.
Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, China.
Int J Tuberc Lung Dis. 2017 Sep 1;21(9):990-995. doi: 10.5588/ijtld.17.0086.
To describe the trends in prevalence of drug-resistant tuberculosis (TB) among in-patients in Beijing Chest Hospital, Beijing, China, using a 10-year retrospective study.
From 2005 to 2014, 18 310 in-patients with TB were recruited for the study, most of whom were referrals; no distinction was made between new and previously treated cases. Drug susceptibility testing (DST) was performed in culture-positive cases using the proportion method to determine multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Risk factors associated with drug resistance were identified.
A total of 5141 (28.0%) samples were culture-positive. DST results showed that 860 (16.7%) cases were MDR-TB and 176 (3.4%) were XDR-TB. MDR-TB and XDR-TB were detected in respectively 21.2% and 12.5% of new cases. The rate of MDR-TB and XDR-TB gradually increased from 2005, with MDR-TB reaching a peak in 2008 and XDR-TB in 2009. These data closely mirror national survey data on this region, patient age and occupation.
Trends in MDR-TB and XDR-TB prevalence during the past decade and their inflection points were determined, which complemented reports from previous national surveys. This information is useful for fighting TB in China.
采用回顾性研究，描述北京胸科医院住院结核病患者中耐药结核病的流行趋势。
2005 年至 2014 年，共招募了 18310 例结核病住院患者，其中大部分为转诊患者；未对新发和复治病例进行区分。采用比例法对培养阳性病例进行药物敏感性试验（DST），以确定耐多药结核病（MDR-TB）和广泛耐药结核病（XDR-TB）。确定与耐药相关的危险因素。
共 5141 例（28.0%）标本培养阳性。DST 结果显示，860 例（16.7%）为 MDR-TB，176 例（3.4%）为 XDR-TB。新发病例中分别有 21.2%和 12.5%为 MDR-TB 和 XDR-TB。MDR-TB 和 XDR-TB 的检出率从 2005 年开始逐渐上升，MDR-TB 在 2008 年达到高峰，XDR-TB 在 2009 年达到高峰。这些数据与该地区全国调查数据、患者年龄和职业密切相关。
确定了过去十年间 MDR-TB 和 XDR-TB 流行率的趋势及其转折点，补充了以往全国调查的报告。这些信息对中国的结核病防治工作具有重要意义。
