β-肾上腺素能受体阻断对运动诱导的血浆儿茶酚胺浓度及其消散曲线的影响。
Effect of beta-adrenoceptor blockade on exercise-induced plasma catecholamine concentrations and their dissipation profile.
作者信息
Ohnishi A, Minegishi A, Sasaki T, Suganuma T, Ishizaki T
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):339-43. doi: 10.1111/j.1365-2125.1987.tb03054.x.
The time-course of plasma noradrenaline (NA) and adrenaline (A) concentrations and their dissipation profiles were examined concomitantly with heart rate changes after strenuous exercise in eight normal subjects receiving either placebo or carteolol, a beta-adrenoceptor blocker. Post-exercise NA concentrations declined with time in a biexponential manner, while A disappearance curves were apparently monophasic. Plasma NA concentrations and their peak value attained within 3 min after exercise were higher in the carteolol than in the placebo phase, whereas there were no significant differences in the first and second disappearance t1/2 between the two trials. The monoexponential t1/2 of A in the carteolol trial was significantly longer than in the placebo trial. Our results suggest that the dissipation profiles of catecholamines released by exercise appear to be affected by beta-adrenoceptor blockade.
在八名接受安慰剂或β-肾上腺素能受体阻滞剂 carteolol 的正常受试者进行剧烈运动后，同时检查了血浆去甲肾上腺素（NA）和肾上腺素（A）浓度的时程及其消散曲线，并观察了心率变化。运动后，NA 浓度随时间呈双指数下降，而 A 的消失曲线明显呈单相。与安慰剂阶段相比，运动后 3 分钟内达到的血浆 NA 浓度及其峰值在 carteolol 阶段更高，而两项试验之间的第一和第二消失半衰期没有显著差异。carteolol 试验中 A 的单指数半衰期显著长于安慰剂试验。我们的结果表明，运动释放的儿茶酚胺的消散曲线似乎受到β-肾上腺素能受体阻滞的影响。
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