Vachiramon Vasanop, Onprasert Woranit, Harnchoowong Sarawin, Chanprapaph Kumutnart
Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Biomed Res Int. 2017;2017:5617838. doi: 10.1155/2017/5617838. Epub 2017 Jul 30.
Vitiligo usually presented as asymptomatic depigmented macules and patches. Little is known regarding itch in vitiligo. This study aimed to evaluate the prevalence and characteristics of itch in vitiligo patients.
A cross-sectional study was conducted on vitiligo patients. Itch character and intensity were determined through questionnaires. Evaluation was also made by dermatologists to define vitiligo subtype, body surface area, Koebner phenomenon (KP), and so on. Data were assessed by computer software. Results were considered statistically significant if < 0.05.
Among 402 patients, itch on vitiliginous lesion presented in 20.2%. Prevalence of itch was most common in focal vitiligo (29.4%), followed by segmental vitiligo (20.3%) and nonsegmental vitiligo (19.6%), respectively. Tingling sensation was the most common itch-related symptom (82.7%). The median itch intensity is 5 by 10-point visual analog scale. Daily activity and sleep disturbance were observed in 60.5% and 39.5% of patients who experience itch. Itch occurred approximately 3 days prior to the development of lesions in 48.1% of patients. Thirty-two patients (78.1%) with both itch and KP type IIb had active disease.
Itch in vitiligo is not uncommon. The presence of itch with KP type IIb may warrant the active vitiligo.
白癜风通常表现为无症状的色素脱失斑和斑块。关于白癜风瘙痒的情况知之甚少。本研究旨在评估白癜风患者瘙痒的患病率及特征。
对白癜风患者进行了一项横断面研究。通过问卷调查确定瘙痒的特征和强度。皮肤科医生还进行了评估，以确定白癜风亚型、体表面积、同形反应（KP）等。数据由计算机软件进行评估。如果P<0.05，则结果被认为具有统计学意义。
在402例患者中，白癜风皮损处瘙痒的发生率为20.2%。瘙痒的患病率在局限性白癜风中最为常见（29.4%），其次分别为节段性白癜风（20.3%）和非节段性白癜风（19.6%）。瘙痒相关症状中最常见的是刺痛感（82.7%）。瘙痒强度的中位数通过10分视觉模拟量表为5分。在有瘙痒的患者中，60.5%的患者日常活动受到影响，39.5%的患者睡眠受到干扰。48.1%的患者瘙痒发生在皮损出现前约3天。32例（78.1%）同时有瘙痒和IIb型同形反应的患者病情处于活动期。
白癜风患者瘙痒并不少见。伴有IIb型同形反应的瘙痒可能提示白癜风处于活动期。
