Department of Pediatric Intensive Care, Nantes University Hospital, Nantes, France.
Neonatal Intensive Care Unit, Argenteuil Hospital, Argenteuil, France.
Eur J Pediatr. 2017 Oct;176(10):1415-1418. doi: 10.1007/s00431-017-2998-5. Epub 2017 Aug 21.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect often presenting with neonatal jaundice and/or hemolytic anemia. G6PD hemolytic events are linked with exposure to a pro-oxidant agent. We here report three cases of initial G6PD crises in breastfed children secondary to maternal consumption of a tonic drink which contains quinine. Quinine was found in breast milk of one of the mothers after she consumed tonic water.
The amount of quinine that is transmitted through breast milk appears to be sufficient to induce G6PD crises in breastfed children. We hence recommend that consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency. What is Known: • G6PD hemolytic events are linked with exposure to a pro-oxidant agent. • Ingestion of fava beans by a mother who was breastfeeding has been reported to induce a neonatal G6PD crisis. What is New: • Maternal consumption of tonic drink which contains quinine appears to be sufficient to induce G6PD crises in breastfed children. • Maternal consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是最常见的人类酶缺陷，常表现为新生儿黄疸和/或溶血性贫血。G6PD 溶血性事件与接触促氧化剂有关。我们在此报告三例母乳喂养的儿童因母亲饮用含有奎宁的滋补饮料而继发的初始 G6PD 危象。其中一位母亲在饮用滋补水后，其母乳中发现了奎宁。
通过母乳传递的奎宁量似乎足以在母乳喂养的儿童中引起 G6PD 危象。因此，我们建议在 G6PD 缺乏症高发人群中，母乳喂养期间应避免饮用含奎宁的苏打水。
•G6PD 溶血性事件与接触促氧化剂有关。•据报道，母乳喂养的母亲摄入蚕豆会引起新生儿 G6PD 危象。
•母亲饮用含有奎宁的滋补饮料似乎足以在母乳喂养的儿童中引起 G6PD 危象。•在 G6PD 缺乏症高发人群中，母乳喂养期间应避免饮用含奎宁的苏打水。
