肿瘤细胞衍生细胞外囊泡的治疗用途
Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles.
作者信息
Liu Jing, Ma Jingwei, Tang Ke, Huang Bo
机构信息
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
The Hubei Clinical Center & Key Laboratory of Bowel Diseases, Wuhan, 430071, China.
出版信息
Methods Mol Biol. 2017;1660:433-440. doi: 10.1007/978-1-4939-7253-1_35.
Extracellular vesicles (EVs) are nanosized membrane vesicles, released by many cell types, which are an ideal drug-delivery system for antitumor therapy. Exosomes, microparticles (MP), and apoptotic bodies are the three main types of EVs. MPs are EVs with size ranges between 100 and 1000 nm. Tumor cell-derived EVs (T-EVs) can serve as a safe and efficient vehicle to specific deliver chemotherapeutic drugs or oncolytic adenoviruses for tumor treatment. In this section, we describe how to prepare EVs for therapeutic use.
细胞外囊泡（EVs）是由多种细胞类型释放的纳米级膜囊泡，是抗肿瘤治疗的理想药物递送系统。外泌体、微颗粒（MP）和凋亡小体是EVs的三种主要类型。MP是大小在100至1000纳米之间的EVs。肿瘤细胞衍生的EVs（T-EVs）可作为一种安全有效的载体，用于特异性递送化疗药物或溶瘤腺病毒以进行肿瘤治疗。在本节中，我们将描述如何制备用于治疗用途的EVs。
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