School of Electric & Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
Gansu Provincial Cancer Hospital, Lanzhou 730050, China.
Future Oncol. 2017 Sep;13(22):1981-1990. doi: 10.2217/fon-2017-0084. Epub 2017 Aug 22.
To investigate the association between NSUN2/IGF-II signature and ovarian cancer survival.
Using a publicly accessible dataset of RNA sequencing and clinical follow-up data, we performed Classification and Regression Tree and survival analyses.
Patients with NSUN2 IGF-II had significantly superior overall and disease progression-free survival, followed by NSUN2 IGF-II , NSUN2 IGF-II and NSUN2 IGF-II (p < 0.0001 for overall, p = 0.0024 for progression-free survival, respectively). The associations of NSUN2/IGF-II signature with the risks of death and relapse remained significant in multivariate Cox regression models. Random-effects meta-analyses show the upregulated NSUN2 and IGF-II expression in ovarian cancer versus normal tissues.
The NSUN2/IGF-II signature associates with heterogeneous outcome and may have clinical implications in managing ovarian cancer.
探讨 NSUN2/IGF-II 特征与卵巢癌生存之间的关联。
使用公开可获得的 RNA 测序和临床随访数据数据集，我们进行了分类和回归树以及生存分析。
NSUN2/IGF-II 患者的总生存和无疾病进展生存均显著改善，其次是 NSUN2/IGF-II、NSUN2/IGF-II 和 NSUN2/IGF-II（总体而言，p<0.0001；无进展生存，p=0.0024）。多变量 Cox 回归模型中，NSUN2/IGF-II 特征与死亡和复发风险的关联仍然显著。随机效应荟萃分析显示，卵巢癌组织中 NSUN2 和 IGF-II 的表达上调。
NSUN2/IGF-II 特征与异质性结局相关，可能对管理卵巢癌具有临床意义。
