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Pharmacology of GABA receptors on skeletal muscle fibres of the locust (Schistocerca gregaria).

作者信息

Scott R H, Duce I R

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):305-11. doi: 10.1016/0742-8413(87)90084-3.

DOI:10.1016/0742-8413(87)90084-3
PMID:2882922
Abstract

GABA and the trans isomer of 4-aminocrotonic acid are equally potent at inducing increases in Cl- conductance when applied to distal extensor tibia muscle fibres of the locust (Schistocerca gregaria). beta-Alanine, norvaline, glycine and norleucine induced conductance increases of less than 5% of GABA responses. C9 and meso-di-GABA did not alter input conductance in a manner consistent with actions on a GABA receptor Cl- channel complex. Picrotoxin and anisatin were equally potent GABA antagonists, however bicuculline and penicillin G did not reduce GABA-induced changes in input conductance. Pentobarbitone, in addition to inducing an increase in K+ conductance, potentiated GABA-induced increases in Cl- permeability.

摘要

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