Dougan D F, Duffield P, Wade D N
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):317-24. doi: 10.1016/0742-8413(87)90086-7.
The mechanism underlying the modulation, by dextroamphetamine and compounds related to phenylethanolamine, of responses to dopamine and serotonin has been studied in the isolated ventricle and aortic bulb of the clam Tapes watlingi. Dextroamphetamine and phenylethanolamine but not cocaine and benztropine have the ability to unmask inhibitory responses to both dopamine and serotonin in the ventricle. Chlordimeform but not clozapine attenuates the inhibitory response to both dextroamphetamine and phenylethanolamine in concentrations which have little or no effect on the inhibitory response to dopamine in the ventricle. Phenylethanolamine, dextroamphetamine, phenylpropylolamine and p-chloro-phenylethanolamine but not octopamine or noradrenaline attenuate the contractile responses to both dopamine and serotonin in preparations of the quiescent aortic bulb. These data show that there are specific receptors for phenylethanolamine in the Tapes heart capable of modulating responses to dopamine and serotonin, and suggests that this biogenic phenethylamine can act as an environmental and physiological factor which may determine how the mollusc heart responds to dopamine.
在蛤仔（Tapes watlingi）的离体心室和主动脉球中，研究了右旋苯丙胺及与苯乙醇胺相关的化合物对多巴胺和5-羟色胺反应的调节机制。右旋苯丙胺和苯乙醇胺而非可卡因和苯海索，能够揭示心室对多巴胺和5-羟色胺的抑制性反应。杀虫脒而非氯氮平，在对心室中多巴胺抑制性反应几乎没有影响或无影响的浓度下，减弱对右旋苯丙胺和苯乙醇胺的抑制性反应。在静态主动脉球制剂中，苯乙醇胺、右旋苯丙胺、苯丙醇胺和对氯苯乙醇胺而非章鱼胺或去甲肾上腺素，减弱对多巴胺和5-羟色胺的收缩反应。这些数据表明，在蛤仔心脏中存在苯乙醇胺的特异性受体，能够调节对多巴胺和5-羟色胺的反应，并表明这种生物源性苯乙胺可作为一种环境和生理因素，可能决定软体动物心脏对多巴胺的反应方式。
