合成肽对非洲大蜗牛（Achatina fulica Férussac）神经节中鉴定出的巨型神经元的影响——II。

Effects of synthetic peptides on giant neurons identified in the ganglia of an African giant snail (Achatina fulica Férussac)--II.

作者信息

Yongsiri A, Kim K H, Takeuchi H, Yanaihara N, Munekata E, Ariyoshi Y

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):353-6. doi: 10.1016/0742-8413(87)90093-4.

Abstract

Thirteen synthetic biologically-active peptides, which were classified into the peptides proposed as neurotransmitters in mammals and invertebrates and neural venom peptides, were investigated for their effects on the following six identifiable giant neurons of an African giant snail (Achatina fulica Férussac): RAPN (right anterior pallial neuron), INN (intestinal nerve neuron), RPeNLN (right pedal nerve large neuron), LPeNLN (left pedal nerve large neuron), d-LPeLN (dorsal-left pedal large neuron) and d-LPeCN (dorsal-left pedal constantly firing neuron). Oxytocin and proctolin at 10(-4)M excited the RAPN membrane potential, whereas FMRFamide at the same concentration inhibited the same neuron. FMRFamide at 10(-4)M markedly inhibited the d-LPeLN membrane potential, sometimes produced inhibition of RPeNLN and LPeNLN, showed varied effects (excitatory or inhibitory) on INN, and had no effect on d-LPeCN. The other peptides examined had almost no effect on any of the neurons tested.

摘要

研究了13种合成生物活性肽对非洲大蜗牛（Achatina fulica Férussac）的以下6种可识别的巨型神经元的作用，这些肽被分类为在哺乳动物和无脊椎动物中被认为是神经递质的肽以及神经毒液肽：RAPN（右前鳃神经元）、INN（肠神经神经元）、RPeNLN（右足神经大神经元）、LPeNLN（左足神经大神经元）、d-LPeLN（背侧-左足大神经元）和d-LPeCN（背侧-左足持续放电神经元）。10⁻⁴M的催产素和促肠肌动肽使RAPN膜电位兴奋，而相同浓度的FMRF酰胺抑制同一神经元。10⁻⁴M的FMRF酰胺显著抑制d-LPeLN膜电位，有时抑制RPeNLN和LPeNLN，对INN表现出不同的作用（兴奋或抑制），对d-LPeCN无作用。所检测的其他肽对所测试的任何神经元几乎都没有作用。