Nagase H, Karaki H, Ozaki H, Urakawa N, Azuma H, Nakajima T
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):411-4. doi: 10.1016/0742-8413(87)90105-8.
A toxic component (pCrTX) of jellyfish Carybdea rastonii (10(-8)-10(-6)g/ml) caused a contraction in both rat aorta and guinea-pig taenia coli which was partially inhibited by indomethacin or aspirin. pCrTX (10(-7)-10(-6)g/ml) relaxed the norepinephrine-induced contraction in rat aorta which was inhibited by removing endothelium or by adding methylene blue. These results suggest that a portion of the pCrTX-induced contraction is due to release of prostaglandin(s) and that the pCrTX-induced relaxation is due to release of an endothelium-derived relaxing factor.
莱氏拟口水母的一种毒性成分（pCrTX，浓度为10⁻⁸ - 10⁻⁶克/毫升）可引起大鼠主动脉和豚鼠结肠带收缩，吲哚美辛或阿司匹林可部分抑制该收缩。pCrTX（10⁻⁷ - 10⁻⁶克/毫升）可舒张去甲肾上腺素引起的大鼠主动脉收缩，去除内皮或加入亚甲蓝可抑制该舒张作用。这些结果表明，pCrTX诱导的部分收缩是由于前列腺素的释放，而pCrTX诱导的舒张是由于内皮源性舒张因子的释放。
