• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

髓系发生拥抱其内在弱点。

Myelopoiesis embraces its inner weakness.

机构信息

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA, and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Nat Immunol. 2017 Aug 22;18(9):953-954. doi: 10.1038/ni.3814.

DOI:10.1038/ni.3814
PMID:28829446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6289289/
Abstract

The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

摘要

在应急造血过程中，髓系和淋巴系细胞的扩增和收缩能力有助于塑造免疫反应。骨桥蛋白的细胞内和可溶性形式的表达在髓系细胞和淋巴系细胞中以不同的方式调节细胞凋亡的阈值，以对抗感染。

相似文献

1
Myelopoiesis embraces its inner weakness.髓系发生拥抱其内在弱点。
Nat Immunol. 2017 Aug 22;18(9):953-954. doi: 10.1038/ni.3814.
2
Tumor-derived osteopontin suppresses antitumor immunity by promoting extramedullary myelopoiesis.肿瘤来源的骨桥蛋白通过促进骨髓外造血来抑制抗肿瘤免疫。
Cancer Res. 2014 Nov 15;74(22):6705-16. doi: 10.1158/0008-5472.CAN-14-1482. Epub 2014 Oct 1.
3
Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis.白细胞介素-27促进造血干细胞向髓系祖细胞的扩增和分化以控制应急髓系造血中的感染
PLoS Pathog. 2016 Mar 18;12(3):e1005507. doi: 10.1371/journal.ppat.1005507. eCollection 2016 Mar.
4
Regulation of myelopoiesis by CD137L signaling.CD137L 信号对髓系细胞生成的调控。
Int Rev Immunol. 2014 Nov-Dec;33(6):454-69. doi: 10.3109/08830185.2014.921163. Epub 2014 Jun 18.
5
CD137 ligand signaling enhances myelopoiesis during infections.CD137 配体信号增强感染期间的髓系细胞生成。
Eur J Immunol. 2013 Jun;43(6):1555-67. doi: 10.1002/eji.201243071. Epub 2013 Apr 24.
6
Cancer-induced systemic myeloid dysfunction: Implications for treatment and a novel nanoparticle approach for its correction.癌症引起的全身性髓系功能障碍：对治疗的影响和一种新型纳米颗粒纠正方法。
Semin Oncol. 2018 Jan;45(1-2):84-94. doi: 10.1053/j.seminoncol.2018.05.001. Epub 2018 May 30.
7
Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis.曲美替尼通过抑制病理性骨髓生成驱动KRAS突变肿瘤的T细胞依赖性控制。
Cancer Res. 2016 Nov 1;76(21):6253-6265. doi: 10.1158/0008-5472.CAN-16-1308.
8
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.骨髓细胞缺陷型 Kit(W-sh) "Sash" 突变小鼠表现出异常的骨髓生成，导致作为髓源性抑制细胞的脾细胞积累。
J Immunol. 2013 Jun 1;190(11):5534-44. doi: 10.4049/jimmunol.1203355. Epub 2013 May 1.
9
Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.前沿：LPS 诱导的应急髓系发生依赖于 TLR4 表达的非造血细胞。
J Immunol. 2012 Jun 15;188(12):5824-8. doi: 10.4049/jimmunol.1103253. Epub 2012 May 14.
10
Myeloid-derived suppressor cells in parasitic infections.寄生虫感染中的髓源抑制性细胞。
Eur J Immunol. 2010 Nov;40(11):2976-85. doi: 10.1002/eji.201040911.

引用本文的文献

1
The Role and Clinical Relevance of Osteopontin in Allergic Airway Diseases.骨桥蛋白在变应性气道疾病中的作用及临床意义
J Clin Med. 2023 Mar 22;12(6):2433. doi: 10.3390/jcm12062433.

本文引用的文献

1
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.分泌型和细胞内骨桥蛋白导致淋巴细胞和髓细胞群体平衡的偏移。
Nat Immunol. 2017 Sep;18(9):973-984. doi: 10.1038/ni.3791. Epub 2017 Jul 3.
2
Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis.坏死性凋亡过程中的磷脂酰丝氨酸外化、“坏死小体”释放及吞噬作用。
PLoS Biol. 2017 Jun 26;15(6):e2002711. doi: 10.1371/journal.pbio.2002711. eCollection 2017 Jun.
3
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.ESCRT-III在混合谱系激酶结构域样蛋白（MLKL）下游发挥作用，以调节坏死性凋亡细胞死亡及其后果。
Cell. 2017 Apr 6;169(2):286-300.e16. doi: 10.1016/j.cell.2017.03.020.
4
Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis.战斗或逃跑：焦亡和坏死性凋亡对紧急造血的调节
Curr Opin Hematol. 2015 Jul;22(4):293-301. doi: 10.1097/MOH.0000000000000148.
5
Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease.阻断骨桥蛋白可减少同种异体反应性 CD8+T 细胞介导的移植物抗宿主病。
Blood. 2011 Feb 3;117(5):1723-33. doi: 10.1182/blood-2010-04-281659. Epub 2010 Nov 30.
6
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.树突状细胞上I型干扰素受体的激活抑制辅助性T细胞17的发育：细胞内骨桥蛋白的作用
Immunity. 2008 Jul 18;29(1):68-78. doi: 10.1016/j.immuni.2008.05.008.
7
Osteopontin is dispensable for protection against high load systemic fungal infection.骨桥蛋白对于抵御高负荷全身性真菌感染并非不可或缺。
Int Immunopharmacol. 2008 Oct;8(10):1441-8. doi: 10.1016/j.intimp.2008.06.001. Epub 2008 Jun 30.
8
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells.骨桥蛋白的可变翻译产生细胞内和分泌型异构体，它们在树突状细胞中介导不同的生物学活性。
Proc Natl Acad Sci U S A. 2008 May 20;105(20):7235-9. doi: 10.1073/pnas.0802301105. Epub 2008 May 14.
9
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.骨桥蛋白的表达对于浆细胞样树突状细胞产生α干扰素至关重要。
Nat Immunol. 2006 May;7(5):498-506. doi: 10.1038/ni1327. Epub 2006 Apr 9.
10
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.骨桥蛋白是一种造血干细胞龛组成成分，对干细胞池大小起负向调节作用。
J Exp Med. 2005 Jun 6;201(11):1781-91. doi: 10.1084/jem.20041992. Epub 2005 May 31.