髓系发生拥抱其内在弱点。
Myelopoiesis embraces its inner weakness.
机构信息
Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA, and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Nat Immunol. 2017 Aug 22;18(9):953-954. doi: 10.1038/ni.3814.
Abstract
The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.
摘要
在应急造血过程中，髓系和淋巴系细胞的扩增和收缩能力有助于塑造免疫反应。骨桥蛋白的细胞内和可溶性形式的表达在髓系细胞和淋巴系细胞中以不同的方式调节细胞凋亡的阈值，以对抗感染。
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