Nimah Jamaluddin, Chen Alexander, Gable Kelly N, Felthous Alan R
Department of Medicine, University of California at Los Angeles, Los Angeles, California.
Department of Psychiatry, School of Medicine, Saint Louis University, St. Louis, Missouri.
J Opioid Manag. 2017 May/Jun;13(3):197-200. doi: 10.5055/jom.2017.0386.
A variety of medications, most notably tricyclic antidepressants, and other antidepressants including venlafaxine have been reported to have triggered manic episodes in patients with bipolar disorder. The synthetic opioid tramadol has also been associated with mania activation. This report describes an unusual case of tramadol-associated mania in a patient without a charted diagnosis of bipolar disorder. However, she had a history of two prior episodes of mania following administration of tramadol that were also believed to be related to medication-induced mood disorder rather than underlying bipolar disorder. We hypothesize that tramadol-associated mania may have an underlying mechanism involving monoamine neurotransmission and increased oxidative stress.
据报道，多种药物，尤其是三环类抗抑郁药以及包括文拉法辛在内的其他抗抑郁药，可引发双相情感障碍患者的躁狂发作。合成阿片类药物曲马多也与躁狂激活有关。本报告描述了一例未明确诊断为双相情感障碍的患者出现曲马多相关性躁狂的罕见病例。然而，她曾有过两次在服用曲马多后出现躁狂发作的病史，当时也被认为与药物诱发的情绪障碍有关，而非潜在的双相情感障碍。我们推测，曲马多相关性躁狂可能有一个涉及单胺神经传递和氧化应激增加的潜在机制。
