Belcastro Vincenzo, Giordano Lucio, Pruna Dario, Peruzzi Cinzia, Casellato Susanna, Barca Salvatore, Carlone Giorgia, Striano Pasquale, Verrotti Alberto
Neurology Unit, Department of Medicine, S. Anna Hospital, Como, Italy.
Pediatric Neuropsychiatric Division, Spedali Civili, Brescia, Italy.
Epilepsy Res. 2017 Oct;136:123-125. doi: 10.1016/j.eplepsyres.2017.08.001. Epub 2017 Aug 14.
We evaluated the long-term prognosis of patients featuring the association of absences and myoclonic epilepsy of infancy. Our cohort consisted of 10 male subjects with mean age at seizure onset of 29 months. Follow-up data included seizure outcome and EEG findings. All individuals received antiepileptic drugs (AEDs) as monotherapy (6 patients) or polytherapy (4 patients) for a mean period of 24 months. Over a 30-60 month evaluation period (mean: 43 months), all patients were seizure-free. Follow-up data after withdrawal of antiepileptic therapy were obtained for a mean period of 22 months. None of the children did develop other age-related epileptic syndrome after AEDs discontinuation. Furthermore, follow-up EEG data after drugs withdrawal were normal and none of the patients showed cognitive impairment. In conclusion, we confirm that absence seizures may occur in association with myoclonic epilepsy of infancy. This condition shows excellent prognosis with either favourable neurologic development and seizure outcome in these children.
我们评估了伴有婴儿失神和肌阵挛性癫痫的患者的长期预后。我们的队列包括10名男性受试者，癫痫发作起始的平均年龄为29个月。随访数据包括癫痫发作结果和脑电图检查结果。所有个体均接受抗癫痫药物（AEDs）单药治疗（6例患者）或联合治疗（4例患者），平均治疗时间为24个月。在30 - 60个月的评估期内（平均：43个月），所有患者均无癫痫发作。抗癫痫治疗停药后的随访数据平均获取时间为22个月。停用AEDs后，没有一个儿童发展为其他与年龄相关的癫痫综合征。此外，停药后的随访脑电图数据正常，且没有患者出现认知障碍。总之，我们证实婴儿失神发作可能与婴儿肌阵挛性癫痫相关。这种情况预后良好，这些儿童的神经发育和癫痫发作结果均良好。
