载有新型麦卢卡蜂蜜配方的水凝胶薄膜，用于治疗慢性伤口感染。
Hydrogel film loaded with new formula from manuka honey for treatment of chronic wound infections.
机构信息
Department of Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt.
Department of Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt.
出版信息
J Glob Antimicrob Resist. 2017 Dec;11:171-176. doi: 10.1016/j.jgar.2017.08.007. Epub 2017 Aug 19.
OBJECTIVES
Chronic wound infections can be effectively treated using hydrogel loaded with an extract from manuka honey.
METHODS
This study was performed on bacterial isolates from patients with infected wounds at Alexandria Main University Hospital (Alexandria, Egypt). Isolates were exposed to hydrogel sheets composed of chitosan and gelatin and loaded with a new formula from manuka honey.
RESULTS
The results illustrate the antibacterial activity of the formula extracted from manuka honey against Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter baumannii, Pseudomonas aeruginosa and Proteus mirabilis. Screening of the hydrogel by electron microscopy showed the ultrastructure of the gel.
CONCLUSIONS
A hydrogel sheet composed of chitosan and gelatin loaded with a new formula extracted from manuka honey can be used as a dressing for chronic infected wounds.
目的
负载有麦卢卡蜂蜜提取物的水凝胶可有效治疗慢性伤口感染。
方法
本研究在埃及亚历山大大学医院（亚历山大）对感染性伤口患者的细菌分离株进行。分离株暴露于壳聚糖和明胶组成的水凝胶片，并负载来自麦卢卡蜂蜜的新配方。
结果
结果表明，麦卢卡蜂蜜提取配方对金黄色葡萄球菌、化脓性链球菌、鲍曼不动杆菌、铜绿假单胞菌和奇异变形杆菌具有抗菌活性。电子显微镜对水凝胶的筛选显示了凝胶的超微结构。
结论
负载有麦卢卡蜂蜜新配方的壳聚糖和明胶水凝胶片可用作慢性感染性伤口的敷料。
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