Gounley John, Draeger Erik W, Randles Amanda
Department of Biomedical Engineering, Duke University, Durham, NC.
Center for Applied Scientific Computing, Lawrence Livermore National Laboratory, Livermore, CA.
Procedia Comput Sci. 2017;108:175-184. doi: 10.1016/j.procs.2017.05.209.
Simulations of the passage of eukaryotic cells through a constricted channel aid in studying the properties of cancer cells and their transport in the bloodstream. Compound capsules, which explicitly model the outer cell membrane and nuclear lamina, have the potential to improve computational model fidelity. However, general simulations of compound capsules transiting a constricted microchannel have not been conducted and the influence of the compound capsule model on computational performance is not well known. In this study, we extend a parallel hemodynamics application to simulate the fluid-structure interaction between compound capsules and fluid. With this framework, we compare the deformation of simple and compound capsules in constricted microchannels, and explore how deformation depends on the capillary number and on the volume fraction of the inner membrane. The computational framework's parallel performance in this setting is evaluated and future development lessons are discussed.
对真核细胞通过狭窄通道的过程进行模拟，有助于研究癌细胞的特性及其在血液中的运输。复合胶囊明确模拟了细胞外膜和核纤层，有潜力提高计算模型的保真度。然而，尚未对复合胶囊通过狭窄微通道进行全面模拟，且复合胶囊模型对计算性能的影响也尚不明确。在本研究中，我们扩展了一个并行血液动力学应用程序，以模拟复合胶囊与流体之间的流固相互作用。利用这个框架，我们比较了简单胶囊和复合胶囊在狭窄微通道中的变形情况，并探讨了变形如何依赖于毛细管数和内膜的体积分数。评估了该计算框架在这种情况下的并行性能，并讨论了未来的发展方向。
