Huang Dongping, Xu Jing, Wang Jinghui, Tong Jiabin, Bai Xiaochen, Li Heng, Wang Zishan, Huang Yulu, Wu Yufei, Yu Mei, Huang Fang
The State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China.
Parkinsons Dis. 2017;2017:9349487. doi: 10.1155/2017/9349487. Epub 2017 Jul 31.
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD. Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. This article will assist with the development of interventions or therapeutic strategies for PD.
帕金森病(PD)的典型脑部病理学特征以及运动和非运动症状已得到充分证实。然而,关于该疾病病因及其病程的细节却仍不太明确。动物模型极大地丰富了我们目前对这种疾病进展的理解。在各种基于神经毒素的PD模型中,1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)小鼠模型是研究最为广泛的模型。在此,我们概述了PD的MPTP小鼠模型中黑质纹状体通路的动态变化。文中探讨了一些病理生理事件,如纹状体多巴胺(DA)浓度降低、酪氨酸羟化酶(TH)蛋白水平降低、TH阳性神经纤维缺失、黑质致密部(SNpc)中TH阳性神经元数量减少以及胶质细胞激活。本文将有助于开发针对PD的干预措施或治疗策略。