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Rare gene variants in a patient with azathioprine-induced lethal myelosuppression.

作者信息

Yang Xiaoxue, Xu Heng, Yang Jun, Yang Li

机构信息

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.

出版信息

Ann Hematol. 2017 Dec;96(12):2131-2133. doi: 10.1007/s00277-017-3112-9. Epub 2017 Aug 22.

DOI:10.1007/s00277-017-3112-9
PMID:28831540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5691095/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c625/5691095/f6888bd4f7a4/277_2017_3112_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c625/5691095/f6888bd4f7a4/277_2017_3112_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c625/5691095/f6888bd4f7a4/277_2017_3112_Fig1_HTML.jpg

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Sci Rep. 2021 Apr 12;11(1):7984. doi: 10.1038/s41598-021-87095-0.
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Front Pharmacol. 2019 Apr 9;10:346. doi: 10.3389/fphar.2019.00346. eCollection 2019.

本文引用的文献

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NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.NUDT15基因多态性改变硫嘌呤代谢及造血毒性。
Nat Genet. 2016 Apr;48(4):367-73. doi: 10.1038/ng.3508. Epub 2016 Feb 15.
2
Inherited genetic variation in childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中的遗传变异
Blood. 2015 Jun 25;125(26):3988-95. doi: 10.1182/blood-2014-12-580001. Epub 2015 May 21.
3
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer.当前医学实践中的硫嘌呤类药物：分子机制及其在治疗相关癌症中的作用
Nat Rev Cancer. 2008 Jan;8(1):24-36. doi: 10.1038/nrc2292.