Elfeky Mariem, Harb Ola, Gertallah Loay
Department of Pathology, Zagazig University Faculty of Medicine, ZAGAZIG, EGYPT.
Turk Patoloji Derg. 2017;1(1):29-40. doi: 10.5146/tjpath.2017.01399.
Endocervical and endometrioid adenocarcinoma have marked overlapping features and the differentiation between them is important for their accurate management. Villin is an actin-binding protein which has an important role in the maintenance of microvilli in epithelial cells and epithelial cell-specific anti-apoptotic protein processes. Pro-Ex-C is a marker for higher-risk human papilloma virus (HPV) which targets the cell cycle proteins causing their overexpression. The aim of the study was to clarify the diagnostic and predictive role of villin, Pro-Ex-C, estrogen receptor (ER) and progesterone receptor (PR) expression in endocervical and endometrioid adenocarcinoma.
We evaluated villin, Pro-Ex-C, ER and PR expressions in 15 cases of endocervical adenocarcinoma and 30 cases of endometrioid adenocarcinoma. We analyzed the diagnostic and predictive role of that panel in both carcinoma subtypes. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated.
Positive villin and Pro-Ex-C expressions were positively correlated with the presence and pattern of cervical stromal invasion (p < 0.05). ER was positive in all cases of endometrioid adenocarcinoma. PR was detected in most cases of endometrioid adenocarcinoma. The differences of villin, Pro-Ex-C, ER and PR expression in endocervical and endometrioid adenocarcinoma was statistically significant (p < 0.05). This methodology for distinguishing endocervical and endometrioid adenocarcinoma had a sensitivity of 100%, a specificity of 100% and a significant prognostic and predictive role.
In conclusion, villin, Pro-Ex-C, ER and PR expressions have diagnostic and predictive roles in endocervical and endometrioid adenocarcinoma.
宫颈内膜腺癌和子宫内膜样腺癌具有显著的重叠特征，区分二者对于准确的治疗管理很重要。绒毛蛋白是一种肌动蛋白结合蛋白，在维持上皮细胞微绒毛及上皮细胞特异性抗凋亡蛋白过程中起重要作用。Pro-Ex-C是高危型人乳头瘤病毒（HPV）的一种标志物，可靶向作用于细胞周期蛋白导致其过度表达。本研究的目的是阐明绒毛蛋白、Pro-Ex-C、雌激素受体（ER）和孕激素受体（PR）表达在宫颈内膜腺癌和子宫内膜样腺癌中的诊断及预测作用。
我们评估了15例宫颈内膜腺癌和30例子宫内膜样腺癌中绒毛蛋白、Pro-Ex-C、ER和PR的表达情况。我们分析了该指标组合在两种癌亚型中的诊断及预测作用。计算了敏感度、特异度、阳性预测值、阴性预测值及准确性。
绒毛蛋白和Pro-Ex-C的阳性表达与宫颈间质浸润的存在及模式呈正相关（p<0.05）。ER在所有子宫内膜样腺癌病例中均呈阳性。PR在大多数子宫内膜样腺癌病例中可检测到。宫颈内膜腺癌和子宫内膜样腺癌中绒毛蛋白、Pro-Ex-C、ER和PR表达的差异具有统计学意义（p<0.05）。这种区分宫颈内膜腺癌和子宫内膜样腺癌的方法敏感度为100%，特异度为100%，具有显著的预后及预测作用。
总之，绒毛蛋白、Pro-Ex-C、ER和PR表达在宫颈内膜腺癌和子宫内膜样腺癌中具有诊断及预测作用。
