Greenamyre T, Penney J B, Young A B, Hudson C, Silverstein F S, Johnston M V
J Neurosci. 1987 Apr;7(4):1022-30. doi: 10.1523/JNEUROSCI.07-04-01022.1987.
There is no known glutamatergic innervation of globus pallidus (GP) in adult mammals, but we report that during postnatal development of the GP there are large, transient increases in both presynaptic high-affinity glutamate uptake and postsynaptic Na+-independent glutamate receptor binding. These glutamatergic markers increase rapidly in rat GP after birth and then decrease to adult levels over a period of weeks. A similar developmental pattern of pallidal glutamate binding was found in human brains. In contrast, binding in rat caudate-putamen (CPu) increases after birth, reaches a peak, and remains constant into adulthood. The results suggest that a glutamatergic pathway transiently innervates the globus pallidus during the perinatal period. Because glutamate is an excitotoxin, this pathway may account, in part, for the basal ganglia damage seen in some forms of cerebral palsy after perinatal hypoxia/ischemia.
在成年哺乳动物中，目前已知苍白球（GP）不存在谷氨酸能神经支配，但我们报告称，在GP的出生后发育过程中，突触前高亲和力谷氨酸摄取和突触后非钠依赖性谷氨酸受体结合均出现大幅短暂增加。这些谷氨酸能标记物在大鼠出生后迅速在GP中增加，然后在数周内降至成年水平。在人类大脑中也发现了苍白球谷氨酸结合的类似发育模式。相比之下，大鼠尾状核-壳核（CPu）中的结合在出生后增加，达到峰值，并在成年期保持恒定。结果表明，谷氨酸能通路在围产期短暂支配苍白球。由于谷氨酸是一种兴奋性毒素，这条通路可能部分解释了围产期缺氧/缺血后某些形式的脑瘫中所见的基底神经节损伤。
