Guo Z Y, Zhang J X, Wu M, Mei Y F, Lin X J, Bu C, Xie Y, Wang J
Department of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Department of Orthopedic Surgery, Sanmen People Hospital, Sanmen, China.
Braz J Med Biol Res. 2017 Aug 17;50(10):e6115. doi: 10.1590/1414-431X20176115.
Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. The strengths of these associations were assessed by pooled odds ratios (OR) and 95% confidence interval (CI). Eight studies documenting a total of 1351 RA cases and 1585 controls were included in this meta-analysis. In the overall analysis, a significant association between the PADI4 -92C/G polymorphism and RA was found in the Chinese population (G vs C: OR=1.32, 95%CI=1.02-1.71; GG+CG vs CC: OR=1.75, 95%CI=1.20-2.53). The subgroup analyses stratified by geographic area(s) and source of controls revealed significant results in South China, in hospital-based studies and population-based studies. In summary, this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the RA incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.
许多研究评估了肽基精氨酸脱亚氨酶4（PADI4）-92C/G多态性与类风湿关节炎（RA）之间的相关性，但结果仍无定论。因此，我们在中国人群中进行了一项荟萃分析，以提供关于PADI4 -92C/G多态性与RA之间关联的综合数据。在PubMed和中文数据库中检索了2016年5月之前发表的符合条件的研究。通过合并比值比（OR）和95%置信区间（CI）评估这些关联的强度。本荟萃分析纳入了8项研究，共1351例RA病例和1585例对照。在总体分析中，在中国人群中发现PADI4 -92C/G多态性与RA之间存在显著关联（G vs C：OR=1.32，95%CI=1.02-1.71；GG+CG vs CC：OR=1.75，95%CI=1.20-2.53）。按地理区域和对照来源分层的亚组分析显示，在中国南方、基于医院的研究和基于人群的研究中结果显著。总之，这项荟萃分析表明，PADI4 -92C/G多态性可能与中国人群的RA发病率相关，尤其是在中国南方。需要对其他种族群体进行进一步研究以得出明确结论。
