作为胶囊制剂填充和药物释放特性指标的内部流动角度。
The angle of internal flow as an indicator of filling and drug release properties of capsule formulations.
作者信息
Newton J M, Bader F
出版信息
J Pharm Pharmacol. 1987 Mar;39(3):164-8. doi: 10.1111/j.2042-7158.1987.tb06242.x.
The cohesiveness of size fractions of acetylsalicylic acid and lactose alone and in various combinations has been determined by estimation of the rate of decrease in volume as a function of tamping under standard conditions. The cohesiveness was quantified in terms of empirically derived characteristic, the angle of internal flow phi. The value of phi was found to decrease with the particle size of acetylsalicylic acid, but not lactose, and was found to be dependent on the relative proportion and particle sizes of acetylsalicylic acid and lactose when blends of powder were studied. The value of the time for 50% of the drug content to be released from a hard gelatin capsule in an in-vitro dissolution test, T50, was found to decrease with decreasing values of omega for capsules containing acetylsalicylic acid alone. For capsules containing powder blends there was no consistent relationship between the value of T50 and phi.
通过在标准条件下根据夯实作用估算体积减少速率，已确定了单独的乙酰水杨酸和乳糖以及各种组合的粒度级分的内聚性。内聚性根据经验得出的特征——内流角φ进行量化。发现φ值随乙酰水杨酸的粒径减小而降低，但乳糖的粒径对其无影响，并且在研究粉末混合物时发现，φ值取决于乙酰水杨酸和乳糖的相对比例及粒径。在体外溶出试验中，发现从硬明胶胶囊中释放50%药物含量的时间值T50，会随着仅含乙酰水杨酸的胶囊ω值的降低而减小。对于含有粉末混合物的胶囊，T50值与φ之间没有一致的关系。
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