Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Clin Endocrinol (Oxf). 2018 Jan;88(1):146-153. doi: 10.1111/cen.13449. Epub 2017 Sep 13.
Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans, and no population-based analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. We aimed to investigate the association of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes.
DESIGN, PATIENTS AND MEASUREMENTS: Linear and logistic regression models were applied to analyse data from 4082 subjects of the German Study of Health in Pomerania. Main outcomes included estimated glomerular filtration rate (eGFR), serum creatinine and cystatin C and chronic kidney disease.
Inverse associations of chemerin with eGFR were observed. The components of the MetS emerged as modulating factors in this relation and enhanced the association. Logistic regression models confirmed the relation between chemerin and eGFR and revealed that each increase in chemerin per 25 ng/mL was associated with an about threefold higher odds of chronic kidney disease [odds ratio 2.72 (95% confidence interval 2.26-3.29)].
Our results demonstrate a strong inverse association between serum chemerin levels and renal function. This association might be explained by MetS-related phenotypes, which lead to renal damage and are associated with increased chemerin levels and/or an impaired renal elimination of chemerin by diseased kidneys.
研究人员发现 chemerin 在啮齿动物的肾脏中高度表达，并认为其可能影响与肾脏损伤相关的代谢综合征（MetS）相关表型。只有少数临床研究探讨了循环 chemerin 与人类肾功能之间的关系，且尚未进行基于人群的分析。MetS 相关表型对假定关联的潜在影响在很大程度上被忽视。我们旨在研究一般人群中血清 chemerin 与肾功能之间的关联，并特别关注 chemerin 与代谢表型之间可能存在的相互作用。
设计、患者和测量：应用线性和逻辑回归模型分析了来自德国波美拉尼亚健康研究的 4082 名受试者的数据。主要结局包括估算肾小球滤过率（eGFR）、血清肌酐和胱抑素 C 以及慢性肾脏病。
我们发现 chemerin 与 eGFR 呈负相关。MetS 的组成部分是这种关系的调节因素，并增强了这种关联。逻辑回归模型证实了 chemerin 与 eGFR 之间的关系，并表明 chemerin 每增加 25ng/mL，患慢性肾脏病的几率就会增加约三倍[比值比 2.72（95%置信区间 2.26-3.29)]。
我们的研究结果表明，血清 chemerin 水平与肾功能之间存在强烈的负相关。这种关联可能是由 MetS 相关表型引起的，这些表型导致肾脏损伤，并与 chemerin 水平升高和/或患病肾脏对 chemerin 的清除能力受损有关。
