Rutkowski Przemyslaw, Sledzinski Tomasz, Zielinska Hanna, Lizakowski Slawomir, Goyke Elzbieta, Szrok-Wojtkiewicz Sylwia, Swierczynski Julian, Rutkowski Bolesław
Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Regul Pept. 2012 Jan 10;173(1-3):55-9. doi: 10.1016/j.regpep.2011.09.005. Epub 2011 Oct 3.
Chemerin is an adipokine associated with metabolic syndrome, systemic inflammation and innate immune system. It has been suggested recently that the decrease in renal function may cause an increase in serum chemerin concentration. In this paper we investigated the effect of kidney transplantation on elevated serum chemerin concentration in dialyzed patients with end stage renal disease (ESRD). Twenty five ESRD patients were tested before and 3months after the kidney transplantation. The control group was comprised of twenty one healthy subjects. Serum chemerin concentrations were measured using commercial ELISA kit, and were related to clinical status, and biomarkers of renal function. We have shown that the kidney transplantation resulted in the decrease of the serum chemerin concentration. Concomitantly, serum creatinine, blood urea nitrogen, phosphate and C-reactive protein concentrations were significantly reduced, while estimated glomerular filtration rate (eGFR), calcium and hemoglobin substantially increased. Univariate regression analysis showed that serum chemerin concentration was positively correlated with serum creatinine and phosphate concentrations and negatively correlated with eGFR. The results presented here indicate that the serum chemerin concentration in patients with ESRD normalizes after the kidney transplantation, and provide additional evidence that serum chemerin concentration is related to renal function.
凯莫瑞蛋白是一种与代谢综合征、全身炎症及固有免疫系统相关的脂肪因子。最近有研究表明，肾功能下降可能会导致血清凯莫瑞蛋白浓度升高。在本文中，我们研究了肾移植对终末期肾病（ESRD）透析患者血清凯莫瑞蛋白浓度升高的影响。对25例ESRD患者在肾移植前及移植后3个月进行了检测。对照组由21名健康受试者组成。使用商用ELISA试剂盒测定血清凯莫瑞蛋白浓度，并将其与临床状况及肾功能生物标志物相关联。我们发现肾移植导致血清凯莫瑞蛋白浓度降低。同时，血清肌酐、血尿素氮、磷酸盐和C反应蛋白浓度显著降低，而估算肾小球滤过率（eGFR）、钙和血红蛋白则大幅升高。单变量回归分析表明，血清凯莫瑞蛋白浓度与血清肌酐和磷酸盐浓度呈正相关，与eGFR呈负相关。本文给出的结果表明，ESRD患者肾移植后血清凯莫瑞蛋白浓度恢复正常，并提供了额外证据证明血清凯莫瑞蛋白浓度与肾功能相关。
