来那度胺治疗继发的嗜酸性粒细胞增多症。
Eosinophilia secondary to lenalidomide therapy.
作者信息
Escudero-Vilaplana V, Osorio-Prendes S, Collado-Borrell R, González-Arias E, Sanjurjo-Sáez M
机构信息
Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
出版信息
J Clin Pharm Ther. 2018 Apr;43(2):273-275. doi: 10.1111/jcpt.12611. Epub 2017 Aug 17.
WHAT IS KNOWN AND OBJECTIVE
Limited data are available on eosinophilia as a drug adverse event. We describe a case of eosinophilia from lenalidomide therapy.
CASE DESCRIPTION
A 50-year-old woman received lenalidomide, dexamethasone and cyclophosphamide as POEMS syndrome treatment. Eosinophil count rose during lenalidomide treatment and decreased in the periods off treatment. Naranjo nomogram suggested a probable association between the use of lenalidomide and eosinophilia.
WHAT IS NEW AND CONCLUSION
Eosinophilia has rarely been described with lenalidomide. This case shows a clear temporal relationship between lenalidomide and eosinophilia.
已知信息与目的
关于嗜酸性粒细胞增多作为药物不良事件的数据有限。我们描述一例来那度胺治疗引起嗜酸性粒细胞增多的病例。
病例描述
一名50岁女性接受来那度胺、地塞米松和环磷酰胺治疗POEMS综合征。在来那度胺治疗期间嗜酸性粒细胞计数升高，在停药期间降低。Naranjo概率量表提示来那度胺使用与嗜酸性粒细胞增多之间可能存在关联。
新发现与结论
来那度胺引起嗜酸性粒细胞增多的情况鲜有报道。该病例显示了来那度胺与嗜酸性粒细胞增多之间明确的时间关系。
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